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siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
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Autophagy Modulators and Neuroinflammation.
Kyoung Sang Cho1, Jang Ho Lee2, Jeiwon Cho2,3
1Department of Biological Sciences, Konkuk University, Seoul, Korea.
Current Medicinal Chemistry
|November 2, 2018
Summary
Autophagy modulators show promise for treating neurological disorders by reducing neuroinflammation. Activating autophagy may offer neuroprotection and combat neurodegenerative diseases linked to inflammation.
Area of Science:
- Neuroscience
- Cell Biology
- Pharmacology
Background:
- Neuroinflammation is central to neurological disorder development.
- Autophagy's role in regulating neuroinflammation is a growing research area.
- Impaired autophagy is implicated in neurodegenerative disease pathogenesis.
Purpose of the Study:
- To review research on autophagy's role in controlling neuroinflammation.
- To evaluate autophagic modulators in mammalian cells and animal models.
- To assess the potential of autophagy modulation for neurological disorders.
Main Methods:
- Review of recent studies on autophagy and neuroinflammation.
- Focus on studies reporting anti-neuroinflammatory effects.
- Inclusion of studies showing autophagy modulators activating neuroinflammation.
Main Results:
- Autophagic modulators exhibit both neuroprotective and anti-neuroinflammatory effects.
- Mechanisms of action and therapeutic limitations are discussed.
- Evidence suggests autophagy modulation impacts neuroinflammation.
Conclusions:
- Autophagy activators are promising for treating neuroinflammatory neurological disorders.
- Targeting autophagy offers a potential therapeutic strategy.
- Further research is needed to explore limitations and optimize treatments.
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