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Regulation of Histone Deacetylases by MicroRNAs in Bone

S Shreya1, D Malavika1, V Raj Priya1

  • 1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.

Current Protein & Peptide Science
|November 2, 2018
PubMed

Insights

MicroRNAs (miRNAs) regulate bone formation by targeting histone deacetylases (HDACs). This review details how specific miRNAs influence HDACs, impacting osteogenesis and bone development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Osteoblast differentiation and new bone formation involve complex signaling pathways (TGF-β, BMP, Wnt) and transcription factors.
  • Histone deacetylases (HDACs) are crucial regulatory factors influencing chromatin structure and gene expression in osteogenesis.
  • MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by targeting messenger RNAs (mRNAs).

Purpose of the Study:

  • To review the miRNAs that target various classes of HDACs.
  • To elucidate the impact of miRNA-mediated HDAC regulation on osteogenesis.

Main Methods:

  • Literature review of recent findings on miRNAs targeting HDACs in bone.
  • Analysis of the regulatory mechanisms of miRNAs and HDACs in osteoblast differentiation.

Main Results:

  • Several miRNAs have been identified that specifically target different classes of HDACs.
  • These miRNA-HDAC interactions play a significant role in modulating osteogenesis.

Conclusions:

  • miRNAs are key regulators of osteogenesis through their targeting of HDACs.
  • Understanding these interactions provides insights into potential therapeutic strategies for bone-related disorders.
Keywords:
BoneHDACsMicroRNAdeacetylationosteogenesisrunx2.

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