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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular

Cecilia Kimani1, Aya Kadota1,2, Katsuyuki Miura1,2

  • 1Center for Epidemiologic Research in Asia, Shiga University of Medical Science.

Journal of Atherosclerosis and Thrombosis
|November 2, 2018
PubMed

Insights

Coronary artery calcification (CAC) and aortic artery calcification (AAC) share similar cardiovascular disease (CVD) risk factors, though the strength of association varies slightly between them.

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Epidemiology

Background:

  • Calcification in coronary and aortic arteries is linked to cardiovascular morbidity and mortality.
  • Aortic artery calcification (AAC) and coronary artery calcification (CAC) have distinct pathophysiological influences.
  • Understanding the differences in risk factor associations is crucial for cardiovascular disease (CVD) prevention.

Purpose of the Study:

  • To compare the associations between coronary artery calcification (CAC) and aortic artery calcification (AAC) with various cardiovascular disease (CVD) risk factors.
  • To investigate potential differences in the strength of these associations.

Main Methods:

  • A random sample of 1035 Japanese men aged 40-79 years was analyzed.
  • Coronary artery calcification (CAC) and aortic artery calcification (AAC) were quantified using computed tomography and the Agatston scoring method.
  • Logistic regression and generalized estimating equations were employed to assess the relationship between calcification scores and CVD risk factors, adjusting for multiple covariates.

Main Results:

  • Both coronary artery calcification (CAC) and aortic artery calcification (AAC) were independently associated with age, systolic blood pressure, and smoking.
  • Alcohol intake showed a significant correlation with aortic artery calcification (AAC) but not coronary artery calcification (CAC).
  • The strength of association between risk factors and calcification varied between CAC and AAC, with age showing a notably stronger link to AAC.

Conclusions:

  • Coronary artery calcification (CAC) and aortic artery calcification (AAC) are associated with a similar set of cardiovascular disease (CVD) risk factors.
  • The magnitude of the association between these risk factors and calcification differs subtly between the coronary and aortic arteries.
Abstract

Keywords:
Aortic arteryCalcificationCardiovascular diseasesCoronary arteryRisk factors

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