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S100 proteins as therapeutic targets.
1Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. anne.bresnick@einstein.yu.edu.
Biophysical Reviews
|November 2, 2018
Summary
This review explores S100 protein family members, their diverse functions, and roles in diseases. It focuses on developing S100 neutralizing antibodies and small molecule inhibitors for therapeutic applications.
Area of Science:
- Molecular Biology
- Cell Biology
- Immunology
Background:
- The human genome encodes 21 S100 protein family members with distinct expression patterns.
- S100 proteins, despite structural similarity, bind diverse targets and regulate crucial cellular functions.
- These proteins are implicated in cancer, autoimmune diseases, and chronic inflammatory disorders.
Purpose of the Study:
- To review the development of S100 neutralizing antibodies.
- To examine small molecule inhibitors targeting S100 proteins.
- To discuss the therapeutic potential of these agents in disease management.
Main Methods:
- Literature review of studies on S100 protein function.
- Analysis of research on S100 neutralizing antibodies.
- Evaluation of small molecule inhibitor development for S100 proteins.
Main Results:
- S100 proteins regulate cell proliferation, migration, invasion, and differentiation.
- Targeting S100 proteins offers potential therapeutic strategies.
- Development of neutralizing antibodies and small molecule inhibitors is advancing.
Conclusions:
- S100 proteins are key regulators in various cellular processes and diseases.
- Therapeutic interventions targeting S100 proteins show promise for disease control.
- Further research into S100-targeted therapies could lead to improved treatment outcomes.
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