Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

16.1K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.1K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.6K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.6K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

53.0K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
53.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppression of microRNAs targeting key MEP pathway genes affects plastid terpenoid content and photosynthesis under variable light conditions.

Molecular biology reports·2026
Same author

Suppression of miR426 enhances photoprotection and chlorophyll stability via upregulation of ELIP2 in Arabidopsis thaliana.

Molecular biology reports·2026
Same author

Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities.

Interdisciplinary sciences, computational life sciences·2025
Same author

Bioengineering of Probiotic Yeast <i>Saccharomyces boulardii</i> for Advanced Biotherapeutics.

ACS synthetic biology·2025
Same author

Molecular Genetics and Probiotic Mechanisms of Saccharomyces cerevisiae var. boulardii.

Probiotics and antimicrobial proteins·2025
Same author

Structural and Functional Analysis of Plant Oil-Body Lipase Eg LIP1 From Elaeis guineensis.

Proteins·2025

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits
09:43

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Published on: January 3, 2025

3.5K

Functional Genomics.

Hoe-Han Goh1, Chyan Leong Ng2, Kok-Keong Loke2

  • 1Institute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia. gohhh@ukm.edu.my.

Advances in Experimental Medicine and Biology
|November 2, 2018
PubMed
Summary
This summary is machine-generated.

Functional genomics integrates biology and bioinformatics to understand gene function. This chapter explores its applications in disease, agriculture, and antibiotic discovery, including a case study on plant volatile compound biosynthesis.

Keywords:
Crop genomicsGenomic medicineMetagenomicsPharmacogenomicsRNA-SeqSequencingTranscriptomics

More Related Videos

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K
Genetic Manipulation in &Delta;ku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

17.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits
09:43

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Published on: January 3, 2025

3.5K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K
Genetic Manipulation in &Delta;ku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

17.6K

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Systems Biology

Background:

  • The post-genomics era generates vast sequencing data, necessitating computational approaches for analysis.
  • Functional genomics aims to understand the blueprint, regulation, and expression of genetic elements.
  • Systems biology provides a framework for integrating diverse biological data.

Purpose of the Study:

  • To discuss the concept and applications of functional genomics.
  • To provide examples in human genetic diseases, crop improvement, and antibiotic discovery.
  • To introduce transcriptomics workflow and present a case study.

Main Methods:

  • Review of functional genomics concepts and applications.
  • Overview of transcriptomics workflow and experimental design.
  • In-house transcriptomics case study on aromatic herbal plants.

Main Results:

  • Functional genomics is crucial for understanding organismal physiology and disease.
  • Applications span human genetics, agriculture, and metagenomics for drug discovery.
  • Transcriptomics analysis revealed insights into plant volatile compound biosynthesis.

Conclusions:

  • Functional genomics, supported by bioinformatics, is essential for interpreting complex biological data.
  • Its applications have broad implications across various scientific and industrial fields.
  • Transcriptomics provides a powerful tool for investigating gene expression and metabolic pathways.