Related Experiment Video
Updated: Feb 3, 2026
08:12
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
6.0K
Circulating miRNA panels for specific and early detection in bladder cancer
Wataru Usuba1,2, Fumihiko Urabe1,3, Yusuke Yamamoto1
1Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Cancer Science
|November 2, 2018
Summary
A novel 7-microRNA (miRNA) panel shows promise for early bladder cancer detection. This blood-based biomarker accurately identifies bladder cancer, potentially improving screening and diagnosis.
Area of Science:
- Oncology
- Molecular Diagnostics
- Biomarker Discovery
Background:
- Bladder cancer is a significant global health concern, marked by high recurrence rates and limitations in current diagnostic methods.
- Conventional screening tools like cystoscopy and urinary cytology suffer from low accuracy or high invasiveness.
- Circulating microRNAs (miRNAs) are emerging as promising biomarkers for non-invasive cancer detection via liquid biopsy.
Purpose of the Study:
- To investigate the potential of global miRNA profiling in serum for diagnosing bladder cancer.
- To identify specific miRNA biomarkers for accurate and early detection of bladder cancer.
- To evaluate a novel 7-miRNA panel for its diagnostic performance in distinguishing bladder cancer from non-cancerous conditions and other malignancies.
Main Methods:
- Global miRNA profiling was conducted on serum samples from 392 bladder cancer patients, 100 non-cancer controls, and 480 other cancer controls.
- Serum samples were randomly allocated into training and validation cohorts (N=486 each).
- Statistical analysis was performed to identify specific miRNAs and a 7-miRNA panel with high diagnostic accuracy.
Main Results:
- A specific miRNA, miR-6087, was identified as a potential diagnostic marker for bladder cancer in both training and validation sets.
- A 7-miRNA panel (including miR-6087, miR-6724-5p, miR-3960, miR-1343-5p, miR-1185-1-3p, miR-6831-5p, and miR-4695-5p) demonstrated high accuracy in discriminating bladder cancer.
- The 7-miRNA panel achieved an Area Under the Curve (AUC) of 0.97, with 95% sensitivity and 87% specificity, irrespective of cancer stage or grade.
Conclusions:
- The identified 7-miRNA panel serves as a potential non-invasive biomarker for the specific and early detection of bladder cancer.
- This miRNA-based approach offers a promising alternative to conventional diagnostic methods, addressing limitations of accuracy and invasiveness.
- Further validation in larger, diverse cohorts is warranted to establish this panel as a clinical diagnostic tool for bladder cancer.
Related Concept Videos
01:18Wood Panel Products
381
Wood panel products are essential materials used in construction for applications such as flooring, siding, and roofing, typically available in standard dimensions of 4 feet by 8 feet, with thicknesses varying from one-quarter of an inch to one and one-eighth inches. Among the most common types of wood panels is plywood, which is produced by gluing multiple layers of thin wood veneers under pressure. The grain of the outer veneers runs lengthwise, while the grains of the interior layers run...
381
01:23Urinary Bladder
3.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.4K
01:21Coronary Circulation
7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
01:14Fetal Circulation
3.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.0K
01:19Overview of Pulmonary Circulation
3.1K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.1K
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
1.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.6K