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Retinal Nerve Fiber Layer Thickness in Children: The Gobi Desert Children Eye Study

Chun-Yan Wang1, Yan-Fei Zheng1, Bin Liu1

  • 1The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Investigative Ophthalmology & Visual Science
|November 2, 2018
PubMed

Insights

Retinal nerve fiber layer thickness (RNFLT) in children varies by region, decreasing with myopia and male sex. Unlike adults, RNFLT in schoolchildren does not decline with age.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Retinal Imaging

Background:

  • Population-based data on retinal nerve fiber layer thickness (RNFLT) in children is limited.
  • Understanding RNFLT in pediatric populations is crucial for early detection of eye conditions.

Purpose of the Study:

  • To measure RNFLT in schoolchildren and investigate its associations.
  • To establish normative RNFLT data for a pediatric cohort.

Main Methods:

  • A population-based study included 1440 schoolchildren aged 6-21 years.
  • Spectral-domain optical coherence tomography (SD-OCT) was used to measure peripapillary RNFLT.
  • Multivariate analysis assessed associations between RNFLT and various factors.

Main Results:

  • Mean global RNFLT was 101.3 ± 9.2 μm.
  • RNFLT exhibited regional variation, thickest temporally inferior and thinnest nasally.
  • RNFLT decreased with higher myopia, male sex, higher intraocular pressure, and lower birth weight.

Conclusions:

  • Pediatric RNFLT shows regional differences and is influenced by refractive error and sex.
  • Unlike adults, RNFLT in children does not decrease with increasing age.
  • Findings provide essential normative data for interpreting RNFLT in children.
Abstract

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