Development of a Selection Method for Discovering Irreversible (Covalent) Binders from a DNA-Encoded Library

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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Zhengrong Zhu1, LaShadric C Grady1, Yun Ding1

  • 11 GlaxoSmithKline, Cambridge, Massachusetts, USA.

SLAS Discovery : Advancing Life Sciences R & D
|November 2, 2018
PubMed

Keywords:
DELDNA-encoded chemical librariesDNA-encoded library technologyaffinity selectionscovalent inhibitorsirreversible inhibitorsselection of covalent binders

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