Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article

Area of Science:

• Cardiology
• Metabolic Disorders
• Epidemiology

Background:

• Hyperuricemia is a metabolic condition characterized by elevated serum uric acid (SUA) levels.
• Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
• The independent contribution of hyperuricemia to CAD requires further elucidation.

Purpose of the Study:

• To determine the independent association between hyperuricemia and coronary artery disease (CAD).
• To explore the relationship between serum uric acid (SUA) levels and the severity of CAD.
• To investigate potential sex-specific differences in these associations.

Main Methods:

• Retrospective cohort study involving 5069 patients undergoing coronary angiography (CAG).
• Patients were categorized based on the presence or absence of hyperuricemia and CAD.
• Statistical analyses, including odds ratios and confidence intervals, were used to assess correlations.

Main Results:

• The incidence of CAD was significantly higher in patients with hyperuricemia (71.5%) compared to those without (66.6%).
• Hyperuricemia showed a significant independent correlation with CAD in women (OR=1.509, P=.009).
• Increasing SUA quartiles were associated with a higher prevalence of CAD and more severe forms (e.g., 3-vessel disease) in women, but not in men.

Conclusions:

• Hyperuricemia is an independent risk factor for coronary artery disease, particularly in women.
• Elevated serum uric acid levels are associated with increased CAD severity, including multi-vessel disease, in the female population.
• These findings highlight the importance of monitoring SUA levels in cardiovascular risk assessment, especially for women.