Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Homeostatic Imbalance01:10

Homeostatic Imbalance

34.1K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
34.1K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

4.2K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.2K
Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Plasticizers01:31

Plasticizers

368
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
368
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Plastic Behavior01:21

Plastic Behavior

579
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
579

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA-138-5p suppresses excitatory synaptic strength at the cerebellar input layer.

The Journal of physiology·2025
Same author

Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria.

Communications biology·2025
Same author

A deep learning framework for automated and generalized synaptic event analysis.

eLife·2025
Same author

A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events.

Neuron·2024
Same author

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.

Nature·2024
Same author

Efficient sampling-based Bayesian Active Learning for synaptic characterization.

PLoS computational biology·2023
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.9K

Homeostatic plasticity-a presynaptic perspective.

Igor Delvendahl1, Martin Müller1

  • 1Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Current Opinion in Neurobiology
|November 2, 2018
PubMed
Summary
This summary is machine-generated.

Homeostatic signaling systems stabilize synaptic transmission. This review focuses on presynaptic homeostatic plasticity (PHP), exploring its mechanisms and evolutionary conservation in neurotransmission.

More Related Videos

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.9K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.6K

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Molecular Biology

Background:

  • Synaptic plasticity underlies learning and memory.
  • Homeostatic signaling maintains stable neural activity.
  • Mechanisms regulate both presynaptic and postsynaptic function.

Purpose of the Study:

  • Review recent advances in presynaptic homeostatic plasticity (PHP).
  • Discuss basic mechanisms of neurotransmitter release.
  • Highlight conserved molecular mechanisms of PHP.

Main Methods:

  • Literature review of recent research on PHP.
  • Analysis of molecular and cellular mechanisms.
  • Comparative study across different species and synapses.

Main Results:

  • PHP is an evolutionarily conserved mechanism.
  • Molecular insights reveal conserved pathways.
  • Similarities observed across diverse synapses.

Conclusions:

  • PHP plays a crucial role in stabilizing synaptic function.
  • Understanding PHP mechanisms offers insights into neural computation.
  • PHP is a fundamental process in maintaining brain function.