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Sleep disorders and endothelial dysfunction in children with sickle cell anemia
Vinícius Ramos-Machado1, Ana Marice Ladeia1, Rozana Dos Santos Teixeira2
1Bahiana School of Medicine and Public Health, Bahiana Foundation for the Development of Sciences Salvador, Bahia, 40080-002, Brazil.
Sleep Medicine
|November 2, 2018
Summary
Children with sickle cell anemia (SCA) experience worse sleep, including sleep-disordered breathing, and have impaired endothelial function. Sleep disturbances correlate with inflammatory markers in these children.
Area of Science:
- Pediatric Hematology
- Sleep Medicine
- Cardiovascular Health
Background:
- Sickle cell anemia (SCA) is a genetic blood disorder impacting red blood cells.
- Sleep disturbances are common in children but understudied in SCA.
- Endothelial dysfunction is a known complication of SCA.
Purpose of the Study:
- To assess sleep characteristics in children with SCA.
- To investigate the association between sleep disorders and endothelial function parameters in children with SCA.
Main Methods:
- Compared Sleep Disturbance Scale for Children (SDSC) scores and endothelial function (flow-mediated dilation, cytokines) in children with SCA and healthy controls (aged 6-18).
Main Results:
- Children with SCA had significantly lower flow-mediated dilation (FMD) values compared to controls.
- SCA patients showed higher scores for sleep-disordered breathing and other sleep disturbances.
- Specific sleep issues correlated with inflammatory cytokines (IL-12p70, IL-1b, TNF-a, IL-6, IL-17A).
- Hydroxyurea use in SCA patients was associated with higher scores on several SDSC subscales.
Conclusions:
- Children with SCA exhibit poorer sleep quality, particularly sleep-disordered breathing, and impaired endothelial function.
- Sleep disturbances in SCA are linked to systemic inflammation.
- Hydroxyurea treatment may influence sleep patterns in children with SCA.
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