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Blood lead levels and multiple sclerosis: A case-control study

Mohammad Dehghanifiroozabadi1, Parisa Noferesti2, Alireza Amirabadizadeh1

  • 1Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Moallem Avenue, Birjand, Iran.

Multiple Sclerosis and Related Disorders
|November 2, 2018
PubMed
Abstract

Insights

Elevated blood lead levels are associated with multiple sclerosis (MS). Higher lead exposure in patients with MS indicates a potential environmental risk factor for this neurological disease.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Toxicology

Background:

  • Multiple sclerosis (MS) is a central nervous system disease characterized by demyelination.
  • Exposure to heavy metals, including lead, is suspected to increase MS incidence.
  • Limited research exists on the correlation between heavy metal concentrations and MS occurrence.

Purpose of the Study:

  • To investigate the relationship between blood lead levels (BLL) and the incidence of multiple sclerosis.
  • To determine if elevated lead exposure is a risk factor for developing MS.

Main Methods:

  • A case-control study involving 29 patients with MS and 29 matched healthy controls.
  • Blood lead levels were quantified using atomic absorption spectrometry.
  • Statistical analysis included Student t-test, Mann-Whitney U, and multiple logistic regression (p < 0.05).

Main Results:

  • Median blood lead levels were significantly higher in MS patients (38 µg/L) compared to controls (30 µg/L).
  • The mean BLL was substantially greater in the MS group (75.6 µg/L) than in the control group (33.8 µg/L).
  • Multiple logistic regression indicated a 1.17-fold increased risk of MS for every 1 µg/L rise in BLL.

Conclusions:

  • Blood lead levels are significantly elevated in individuals with multiple sclerosis.
  • Increased blood lead levels are associated with a higher risk of developing MS, suggesting lead exposure as a potential environmental factor.
Keywords:
Case-control StudyLead, PbMultiple sclerosis

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