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Updated: Feb 3, 2026
Production and Measurement of Organic Particulate Matter in the Harvard Environmental Chamber
Published on: November 18, 2018
Ozonation of valsartan: Structural elucidation and environmental properties of transformation products
Miriam Diehle1, Wilhelm Gebhardt1, Johannes Pinnekamp1
1Environmental Analytical Laboratory, Institute of Environmental Engineering, RWTH Aachen University, Mies-van-der-Rohe-Str. 1, 52074 Aachen, Germany.
Abstract:
The pharmaceutical valsartan is classified as a trace organic compound and is released into wastewater from human consumption. Trace organic compounds are not completely removed during conventional wastewater treatment. In order to prevent their release into the aquatic environment, advanced wastewater treatment technologies such as ozonation are currently implemented. Ozonation leads to the formation of transformation products (TPs), which then enter the receiving waters. In the present work, laboratory-scale ozonation experiments of valsartan solutions were performed. The resulting TPs were analyzed by HPLC-MS and searched for using a non-targeted approach. Of the 51 compounds detected, 27 have tentative structural suggestions based on MS/MS experiments. Ozonation of valsartan does not lead to the formation of TPs with higher toxicity towards A. fischeri than the parent compound. According to QSAR-based environmental behavior estimations, most TPs reveal lower lipophilicity, increased biodegradability as well as decreased acute and chronic toxicities concerning fish, daphnia and algae compared to their parent compound valsartan.
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