Related Experiment Video

Updated: Feb 3, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

16.3K

Factors Affecting Adherence to Antihypertensive Medication

Hyo Yoon Choi1, Im Jung Oh1, Jung Ah Lee1

  • 1Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.

Korean Journal of Family Medicine
|November 3, 2018
PubMed

Insights

Older age, exercise, and multiple antihypertensive medications improve adherence in patients with hypertension. High salt intake is linked to poor medication adherence, highlighting key factors for better hypertension control.

Area of Science:

  • Cardiology
  • Public Health
  • Pharmacology

Background:

  • Hypertension significantly contributes to the global burden of cardiovascular and cerebrovascular diseases.
  • Effective management of hypertension relies heavily on patient adherence to prescribed antihypertensive medications.

Purpose of the Study:

  • To identify demographic and clinical factors associated with adherence to antihypertensive medication among Korean patients.
  • To inform strategies for improving hypertension management and control.

Main Methods:

  • A cohort of 1,523 Korean patients with hypertension was recruited from urban and metropolitan healthcare facilities.
  • Medication adherence was assessed using the pill count method (≥80% as good adherence).
  • Sociodemographic, lifestyle, and clinical data were analyzed using chi-square and t-tests, with logistic regression for adherence predictors.

Main Results:

  • Good adherence to antihypertensive medication was observed in 81.7% of patients.
  • Factors associated with good adherence included older age (≥65 years), regular exercise, treatment at metropolitan hospitals, use of multiple antihypertensive medication classes, and concomitant diabetes medication.
  • A family history of hypertension or cardiovascular disease was also linked to better adherence, while high salt intake correlated with poor adherence.

Conclusions:

  • Multiple antihypertensive medication classes, concomitant medications, and regular exercise are positively associated with good adherence.
  • High salt intake is a significant factor associated with poor adherence to antihypertensive therapy.
  • These identified factors are crucial for developing targeted interventions to enhance hypertension control.
Abstract

Keywords:
AdherenceAssociated FactorsHypertensionPatient Compliance

More Related Videos

Clonogenic Assay: Adherent Cells05:30

Clonogenic Assay: Adherent Cells

Published on: March 13, 2011

49.2K
Author Spotlight: In Vitro Endometrial Models to Study Epithelial-Stroma and Embryo Interactions05:58

Author Spotlight: In Vitro Endometrial Models to Study Epithelial-Stroma and Embryo Interactions

Published on: November 8, 2024

1.3K

Related Concept Videos

Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.2K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.4K
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
801
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.8K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.3K
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.5K