[Research progress in the role of intestinal dendritic cells in food allergy]

Food allergy (FA) seriously affects people's quality of life, and its mechanism and effective treatment methods need further study. Intestinal dendritic cells (DCs) can recognize food allergens in FA through multiple pattern recognition receptors, which can be affected by food processing and the addition of additives. In the subsequent allergen presentation process, more and more co-stimulatory molecules have been found to be involved in the polarization of T cells to type 2 helper T cells (Th2 cells), which is facilitated by many endogenous and exogenous substances. DCs may lead to a vicious cycle in the effective phase of FA. DCs also play an important role in the establishment of food tolerance. DC-based oral immunotherapy, bacterial therapy, high-fiber diet and breastfeeding may be used in the prevention and treatment of FA in the future. It is of great significance to study the mechanism of FA and tolerance and explore the effective treatment of FA from the perspective of DCs.