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[Good practices in prescribing benzodiazepines].

Alexis Revet1, Antoine Yrondi2, François Montastruc3

  • 1Centre hospitalier universitaire, service universitaire de psychiatrie de l'enfant et de l'adolescent, 31000 Toulouse, France.

Presse Medicale (Paris, France : 1983)
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Benzodiazepines and z-drugs require short-term use due to tolerance and dependence. Prescribers must consider pharmacokinetics, side effects, and discontinuation when prescribing these medications.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy

Background:

  • Benzodiazepines and z-drugs are commonly prescribed for short-term treatment.
  • Pharmacologic tolerance and dependence necessitate cautious use.

Purpose of the Study:

  • To outline key considerations for the safe and effective prescription of benzodiazepines and z-drugs.
  • To emphasize the importance of patient-prescriber communication regarding risks and duration.

Main Methods:

  • Review of pharmacokinetic properties relevant to drug selection.
  • Analysis of treatment guidelines and adverse event profiles.

Main Results:

  • Prescribers must consider galenic form, plasma half-life, and active metabolites.
  • Concurrent prescription of multiple benzodiazepines offers no additional benefit and increases risks.
  • Adverse events and discontinuation strategies should be discussed prior to treatment initiation.

Conclusions:

  • Short-term use, not exceeding recommended durations, is crucial for benzodiazepines and z-drugs.
  • Informed patient-prescriber dialogue is essential for managing risks associated with these medications.