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Oncofertility: What can we do from bench to bedside?

Hua Zhao1, Lei Jin2, Yufeng Li2

  • 1Institute of Reproductive Medicine, Henan Provincial People's Hospital & People's Hospital of Zhengzhou University, Zhengzhou, Henan, PR China; Department of Gynaecology and Obstetrics, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China.

Cancer Letters
|November 3, 2018
PubMed
Summary

Cancer treatments can cause infertility. Fertility preservation is crucial for young cancer patients to protect reproductive and endocrine functions, enabling future parenthood after remission.

Keywords:
CancerEmbryo cryopreservationFemale fertility preservationMale fertility preservation

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Area of Science:

  • Oncofertility
  • Reproductive Medicine
  • Oncology

Background:

  • Cancer treatments like chemotherapy and radiotherapy can lead to premature ovarian insufficiency (POI) and male germ cell loss.
  • POI and germ cell loss significantly impact cancer survivors' quality of life and future reproductive options.
  • Early consultation for fertility preservation is recommended for all young cancer patients.

Purpose of the Study:

  • To review background knowledge, methods, and applications of fertility preservation in cancer patients.
  • To discuss new strategies for future fertility conservation and endocrine function protection.
  • To raise awareness among physicians regarding the importance of oncofertility.

Main Methods:

  • Review of existing literature on fertility preservation techniques.
  • Discussion of indications, pros, and cons of various methods.
  • Exploration of experimental and clinical applications.

Main Results:

  • Fertility preservation strategies exist to mitigate treatment-induced reproductive damage.
  • Personalized approaches are needed based on patient condition, tumor type, and treatment.
  • Further research can enhance fertility preservation and endocrine function maintenance.

Conclusions:

  • Fertility preservation is vital for young cancer patients facing gonadotoxic treatments.
  • Oncofertility aims to help cancer survivors achieve parenthood and maintain endocrine health.
  • Developing personalized fertility conservation strategies is key for long-term patient well-being.