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Updated: Feb 3, 2026
A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin
Yanmei Chen1, Xuefang Shang2, Congshu Li1
1Key Laboratory of Medical Molecular Probes, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Abstract:
A series of chemsensors (1-4) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H2S. The advantages of the synthesized fluorescent probe (compound 1) were the low detection limit (4 × 10-6 mol·L-1), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds (1 and 2) was studied and the results indicated that compounds (1 and 2) showed almost no cytotoxicityat at a concentration of 150 μg·mL-1. The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe 1 can also detect HS- selectively by naked eye in pure DMSO solvent.
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