Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

2,2'-Bipyridine and hydrazide containing peptides for cyclization and complex quaternary structural control.

Erik T Hernandez1, P Rogelio Escamilla1, Sang-Yop Kwon1

  • 1Department of Chemistry, University of Texas at Austin, Austin, TX, 78712-1224, USA.

New Journal of Chemistry = Nouveau Journal De Chimie
|November 3, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Age-Related Hearing Loss on Brain Connectivity and Cognitive Performance: A Systematic Review.

Trends in hearing·2026
Same author

Electrochemical sequencing of sequence-defined ferrocene-containing oligourethanes.

Chem·2026
Same author

Diagnostic Accuracy and Acceptability of a Mobile Health Hearing Screening Program for Older Adults in Primary Care: A Multicenter Study.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

Beyond sequence similarity: toward function-based screening of nucleic acid synthesis.

Frontiers in bioengineering and biotechnology·2026
Same author

Correction to "Synthesis of Reversible Sequence-Defined Oligourethane Macrocycles through Click and Declick Thiol-Amine Conjugation with a Meldrum's Acid Derived Conjugate Acceptor".

The Journal of organic chemistry·2026
Same author

Self-Limiting Polymerization-Induced Crystallization-Driven Self-Assembly (SL-PI-CDSA) Enables Templated Synthesis of Chiral Plasmonic, Hybrid 2D Hexagonal Assemblies.

Angewandte Chemie (International ed. in English)·2026

Synthetic peptides modified with specific bipyridine ligands show selective metal binding. The 5-position bipyridine peptides bind Fe2+ and Zn2+, enabling macrocycle formation and controlled quaternary structures.

Area of Science:

  • Synthetic chemistry
  • Coordination chemistry
  • Peptide chemistry

Background:

  • Nε-methyl lysine residues in peptides can be functionalized.
  • Bipyridine ligands are known for their metal-chelating properties.

Purpose of the Study:

  • To synthesize and characterize peptide-bipyridine conjugates.
  • To investigate the effect of bipyridine substitution position on metal binding.
  • To explore the formation of complex peptide structures through metal coordination and cyclization.

Main Methods:

  • Chemical synthesis of peptide-bipyridine conjugates.
  • Metal ion binding assays (Fe2+, Zn2+).
  • Spectroscopic characterization of resulting complexes.
  • Investigation of macrocycle and quaternary structure formation.

Related Experiment Videos

Main Results:

  • Peptides with 6-position bipyridine did not bind Fe2+ or Zn2+.
  • Peptides with 5-position bipyridine successfully bound Fe2+ and Zn2+.
  • The presence of a free bipyridine derivative induced macrocycle formation.
  • Hydrazone formation facilitated the creation of complex, controlled quaternary peptide structures.

Conclusions:

  • The position of bipyridine substitution on the peptide is critical for metal ion coordination.
  • Peptide-bipyridine conjugates offer a versatile platform for constructing metallo-supramolecular architectures.
  • This approach allows for the design of complex and controlled peptide-based structures with potential applications in materials science and drug delivery.