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Updated: Feb 3, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Comparison of hepatitis C virus testing recommendations in high-income countries
Risha Irvin1, Kathleen Ward2, Tracy Agee2
1Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. rirvin1@jhmi.edu.
Aim:
To investigate hepatitis C virus (HCV) testing recommendations from the United States and other high-income countries.
Methods:
A comprehensive search for current HCV testing recommendations from the top quartile of United Nations Human Development Index (HDI) countries (very high HDI) was performed using Google and reviewed from May 1 - October 30, 2014 and re-reviewed April 1 - October 2, 2017.
Results:
Of the 51 countries identified, 16 had HCV testing recommendations from a government body or recommendations issued collaboratively between a government and a medical organization. Of these 16 countries, 15 had HCV testing recommendations that were primarily risk-based and highlight behaviors, exposures, and conditions that are associated with HCV transmission in that region. In addition to risk-based testing, the HCV Guidance Panel (United States) incorporates recommendations for a one-time test for individuals born during 1945-1965 (the birth cohort) without prior ascertainment of risk into their guidance. In addition to the United States, six other countries either have an age-based testing recommendation or recommend one-time testing for all adults independent of risk factors typical of the region.
Conclusion:
This review affirmed the similarities of the HCV Guidance Panel's guidance with those of recommendations from very high HDI countries.
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