Occult radiopaque jaw lesions in familial adenomatous polyposis coli and hereditary nonpolyposis colorectal cancer
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Summary
This summary is machine-generated.Occult jaw lesions are linked to adenomatous polyposis coli in some families. These jaw lesions can predict polyp development in families with adenomatous polyposis coli and jaw lesions.
Area Of Science
- Genetics
- Oncology
- Radiology
Background
- Colorectal cancer (CRC) encompasses hereditary nonpolyposis colorectal cancer (HNPCC) and adenomatous polyposis coli (APC).
- Jaw lesions are radiopaque findings in the jawbone.
- The association between jaw lesions and CRC syndromes is not fully understood.
Purpose Of The Study
- To investigate the association between APC, HNPCC, and jaw lesions in 10 pedigrees.
- To determine if jaw lesions predict adenomatous polyposis development.
Main Methods
- Examined 10 pedigrees for APC, HNPCC, and jaw lesions.
- Observed 12 at-risk children (under 16) for APC development.
- Analyzed dental radiographs for jaw lesions.
Main Results
- Seven APC kindreds showed jaw lesions in all polyp patients; one kindred had no jaw lesions.
- One HNPCC kindred had no jaw lesions; the other had generalized jaw lesions in the affected patient.
- Seven of 12 at-risk children with jaw lesions developed polyps within 4 years; five without jaw lesions remained polyp-free for 5-10 years.
Conclusions
- Jaw lesions are consistently found in some APC families, suggesting syndrome heterogeneity.
- Jaw lesions are strong predictors of polyp development in APC kindreds with jaw lesions.
- Further research is needed to explore jaw lesions' role as markers in HNPCC.