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Use of baclofen in children with dysfunctional voiding: a preliminary report

Mehdi Shirazi1, Zahra Jahnabadi1, Pooya Hekmati1

  • 1Shiraz University of Medical Sciences, Namazee Hospital, Department of Urology, Shiraz, Iran.

Central European Journal of Urology
|November 3, 2018
PubMed

Insights

Baclofen effectively treats pediatric dysfunctional voiding (DV), significantly reducing symptoms like urgency and wetting. This study found baclofen safe and well-tolerated in children with DV.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Dysfunctional voiding (DV) is a common condition in children.
  • Effective and safe treatment options for pediatric DV are needed.

Purpose of the Study:

  • To evaluate the efficacy and safety of baclofen for treating pediatric dysfunctional voiding (DV).

Main Methods:

  • Thirty children diagnosed with primary DV participated.
  • Treatment involved oral baclofen (1 mg/kg/day in 3 doses) for 3 months.
  • Assessments included uroflowmetry, post-void residual urine (PVRU) analysis, and the Dysfunctional Voiding Symptom Score (DVSS) questionnaire.

Main Results:

  • Baclofen treatment led to a significant decrease in PVRU (mean 14.67 ml) and DVSS scores (mean 12.3).
  • Key symptoms such as urgency, dysuria, and straining were significantly reduced.
  • Improvements were noted in maximum flow rate (Qmax) and voluntary voiding episodes, with a reduction in wetting episodes.

Conclusions:

  • Baclofen demonstrates potential as a safe and effective treatment for pediatric dysfunctional voiding.
  • The medication was well-tolerated and associated with significant symptom improvement in children.
Abstract

Keywords:
baclofenchildrendysfunctional voiding

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