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Updated: Feb 3, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

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Meta-analysis of microarray datasets identify several chromosome segregation-related cancer/testis genes potentially

Mu Liu1,2, Yu-Lu Qiu1, Tong Jin3

  • 1The First Medical School of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.

Peerj
|November 3, 2018
PubMed
Abstract

Insights

Anaplastic thyroid carcinoma (ATC) is a lethal cancer requiring new treatments. This study identified key cell cycle genes, particularly those involved in chromosome segregation, as potential therapeutic targets for ATC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Anaplastic thyroid carcinoma (ATC) represents the most aggressive form of thyroid cancer, necessitating the discovery of novel therapeutic targets.
  • Current treatment strategies for ATC are limited, highlighting an urgent need for innovative drug development.

Purpose of the Study:

  • To identify and characterize novel molecular targets for Anaplastic Thyroid Carcinoma (ATC) therapy.
  • To investigate the role of cell cycle regulation and chromosome segregation in ATC pathogenesis.

Main Methods:

  • Systematic retrieval and merging of Gene Expression Omnibus (GEO) datasets.
  • Differential gene expression analysis and pathway enrichment analysis.
  • Protein-protein interaction networks, weighted gene co-expression network analysis, and cancer/testis expression pattern analysis were used to predict key genes, further validated with The Cancer Genome Atlas (TCGA) data and Gene Ontology (GO) annotation.

Main Results:

  • Upregulated genes in ATC were significantly enriched in cell cycle-related pathways.
  • Ten key cell cycle-related genes with cancer/testis expression patterns were identified: TRIP13, DLGAP5, HJURP, CDKN3, NEK2, KIF15, TTK, KIF2C, AURKA, and TPX2.
  • These identified genes are critical components involved in chromosome segregation during cell division.

Conclusions:

  • Several key genes with potential therapeutic value for ATC have been predicted.
  • Cell cycle processes, specifically chromosome segregation, are implicated as crucial drivers of ATC tumorigenesis and potential therapeutic targets.
Keywords:
Anaplastic thyroid carcinomaBioinformaticsCancer/testis geneChromosome segregationKey genes identificationMeta-analysis of microarray datasets

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