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Clinics in diagnostic imaging (191). Multiple system atrophy-cerebellar type (MSA-C)
Mark Christopher Pearce1, Garry Choy2, Robert Chun Chen3
1Department of Medical Imaging, Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.
Singapore Medical Journal
|November 3, 2018
Summary
Multiple system atrophy-cerebellar type (MSA-C) is a neurodegenerative disorder. This case highlights key clinical and imaging features for accurate diagnosis and management of this rare condition.
Area of Science:
- Neurodegenerative diseases
- Neurology
- Neuroradiology
Background:
- Multiple system atrophy (MSA) is a rare, sporadic, adult-onset neurodegenerative disorder characterized by autonomic dysfunction, parkinsonism, and cerebellar dysfunction.
- The cerebellar subtype (MSA-C) predominantly affects cerebellar pathways, leading to ataxia and coordination issues.
Observation:
- A 49-year-old Chinese male presented with progressive ataxia, dysphagia, and urinary symptoms.
- Neuroimaging revealed characteristic findings of a cruciform pontine T2-weighted hyperintensity and selective cerebellar and pontine atrophy.
Findings:
- The observed clinical presentation and magnetic resonance imaging (MRI) findings strongly supported a diagnosis of multiple system atrophy-cerebellar type (MSA-C).
- The specific radiological pattern, including pontine hyperintensity and cerebellar atrophy, is a hallmark of MSA-C.
Implications:
- Early and accurate diagnosis of MSA-C is crucial for appropriate patient management and supportive care.
- Understanding the radiological characteristics aids in differentiating MSA-C from other neurodegenerative ataxias.
- Further research into the mechanisms and potential treatments for MSA-C is warranted.
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