Related Experiment Video

Updated: Feb 3, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K

Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond

Amin Pastaki Khoshbin1,2, Mahsa Eskian1,3,4, Mahsa Keshavarz-Fathi1,2,3,5

  • 1Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Archivum Immunologiae Et Therapiae Experimentalis
|November 3, 2018
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) are crucial in cancer metastasis by interacting with the tumor microenvironment. Understanding how these cells promote cancer spread is key to developing new treatments.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Metastasis is a complex process driven by cancer cells and host interactions.
  • Myeloid-derived suppressor cells (MDSCs) are key regulators within the tumor microenvironment.
  • MDSCs are implicated in promoting cancer progression and immune suppression.

Purpose of the Study:

  • To review and discuss the multifaceted mechanisms by which MDSCs contribute to cancer metastasis.
  • To highlight the role of MDSCs in facilitating cancer dissemination.

Main Methods:

  • Literature review and synthesis of existing research on MDSCs and metastasis.
  • Analysis of the molecular and cellular interactions involving MDSCs in the metastatic cascade.

Main Results:

  • MDSCs suppress anti-tumor immunity, a primary function.
  • MDSCs actively promote metastasis through various mechanisms including.
  • These mechanisms include influencing epithelial-mesenchymal transition, cancer stem cell formation, angiogenesis, premetastatic niche establishment, and supporting cancer cell survival at metastatic sites.

Conclusions:

  • MDSCs are critical mediators of cancer metastasis.
  • Targeting MDSCs presents a potential therapeutic strategy to control cancer spread.
Keywords:
AngiogenesisApoptosisImmunosuppressionMetastasisMyeloid-derived suppressor cellsPremetastatic niche

More Related Videos

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.8K
Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

28.2K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.6K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.3K
Role of Microtubules in Cell Wall Deposition01:02

Role of Microtubules in Cell Wall Deposition

Microtubules are small hollow tubes in eukaryotic cells. The cell wall microtubules are polymerized dimers of two globular proteins, α-tubulin and β-tubulin, two globular proteins. With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression and provide a track along which vesicles move through the cell or pull replicated chromosomes to opposite ends of a dividing cell. Microtubules go through quick cycles of...
3.1K