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Updated: Feb 3, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
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The physics of radioembolization.
Remco Bastiaannet1, S Cheenu Kappadath2, Britt Kunnen3
1Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Room E01.132, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands. r.bastiaannet@umcutrecht.nl.
EJNMMI Physics
|November 3, 2018
Summary
Current radioembolization activity prescription methods may be suboptimal for liver cancer patients. Research is needed to develop personalized dosimetry for improved tumor control and treatment feasibility.
Area of Science:
- Medical Physics
- Oncology
- Radiology
Background:
- Radioembolization is a palliative treatment for unresectable liver cancers.
- Current semi-empirical methods are widely used but may be suboptimal.
- Recent trials show limited survival benefits, suggesting a need for improved methods.
Purpose of the Study:
- To evaluate current radioembolization dosimetry methods and their limitations.
- To review advancements in image-guided dosimetry and radiobiological modeling.
- To identify areas for future research toward personalized treatment.
Main Methods:
- Literature review of current dosimetric methods.
- Evaluation of image-guided dosimetry and radiobiological modeling.
- Exploration of dose-response relationships and quantitative image reconstruction.
Main Results:
- Current dosimetry methods have caveats and may not be optimal for all patients.
- Image-guided dosimetry and advanced modeling show promise.
- Robust dose-response relationships are being explored.
Conclusions:
- Personalized dosimetry is crucial for optimizing radioembolization outcomes.
- Further research in quantitative imaging and modeling is necessary.
- Developing clinically feasible, personalized treatments is the ultimate goal.
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