Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncocytic liver cell adenoma.

J R Salisbury, B C Portmann

    Histopathology
    |May 1, 1987
    PubMed
    Summary

    Oncocytic liver cell adenoma, a rare liver tumor, presents challenges in diagnosis. Electron microscopy is crucial for identifying its characteristic abundant mitochondria, aiding differentiation from other liver cancers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The clinical and histopathological spectrum of neutrophilic inflammatory disease encountered in the setting of myelodysplastic syndrome.

    Clinical and experimental dermatology·2021
    Same author

    Multiple skin nodules in a newborn.

    Clinical and experimental dermatology·2019
    Same author

    Tender, subcutaneous nodules in an unwell patient.

    Clinical and experimental dermatology·2012
    Same author

    Acquired epidermodysplasia verruciformis due to multiple and unusual HPV infection among vertically-infected, HIV-positive adolescents in Zimbabwe.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2012
    Same author

    Manganese-enhanced MRI predicts the histological grade of hepatocellular carcinoma in potential surgical candidates.

    Clinical radiology·2011
    Same author

    Polymorphic eruption of pregnancy in a photodistribution: a potentially new association?

    Clinical and experimental dermatology·2009

    Area of Science:

    • Hepatobiliary pathology
    • Tumor biology
    • Diagnostic electron microscopy

    Background:

    • Liver cell adenomas (LCAs) are benign liver tumors often found in women.
    • Distinguishing LCAs from malignant liver tumors like hepatocellular carcinoma (HCC) is critical for patient management.
    • Oncocytic changes in liver tumors can complicate histopathological diagnosis.

    Observation:

    • A case of a solitary liver tumor in a 46-year-old woman is presented.
    • Macroscopic and light microscopy suggested liver cell adenoma.
    • Tumor cells exhibited oncocytic features, characterized by abundant eosinophilic cytoplasm.

    Findings:

    • Electron microscopy confirmed the presence of numerous mitochondria within the tumor cells, consistent with oncocytes.
    • The oncocytic variant of liver cell adenoma can mimic other liver neoplasms.
    • Histopathological differentiation between oncocytic LCA and fibrolamellar HCC can be challenging.

    Implications:

    • Accurate diagnosis of oncocytic liver cell adenoma is essential to avoid misclassification as malignancy.
    • Electron microscopy plays a vital role in characterizing oncocytic tumors.
    • Further studies may be needed to establish definitive diagnostic criteria for oncocytic LCA and its distinction from fibrolamellar HCC.

    Related Experiment Videos