Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.1K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K
Depressants01:28

Depressants

436
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
436
Depression: Overview01:18

Depression: Overview

883
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
883
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

498
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
498

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic multi-domain screening of lead-specific electrocardiographic features associated with sudden cardiac death.

Journal of electrocardiology·2026
Same author

Financial Toxicity: Inequities and Impact on Cardiovascular Disease.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

A child with a large ostium secundum atrial septal defect, pulmonary hypertension, and the characteristic Crochetage electro-vectorcardiographic pattern.

Journal of electrocardiology·2026
Same author

Prognostic implications of intraventricular conduction disorders for the risk of sudden cardiac death in cardiac patients.

Heart rhythm·2026
Same author

Performance of the 12-lead ECG in predicting short- and long-term risk of sudden cardiac death.

NPJ digital medicine·2026
Same author

The evolution of cardiac changes after breast cancer adjuvant radiotherapy - A six-year follow-up study.

Clinical and translational radiation oncology·2025

Related Experiment Video

Updated: Feb 3, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia
07:57

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

17.2K

Upsloping ST depression: Is it acute ischemia?

Mahboob Alam1, Kjell Nikus2, Miguel Fiol3

  • 1The Section of Cardiology, Baylor College of Medicine and Texas Heart Institute, Baylor St Luke Medical Center, Houston, Texas.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|November 3, 2018
PubMed
Summary

This case study details acute coronary syndrome caused by left circumflex artery dissection. Occlusion during stenting led to a myocardial infarction pattern mimicking right coronary artery infarction.

Keywords:
ST depressionaVRacute coronary syndromecoronary artery dissectionelectrocardiogram

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.8K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.1K

Related Experiment Videos

Last Updated: Feb 3, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia
07:57

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

17.2K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.8K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.1K

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Diagnostic Electrocardiography

Background:

  • Acute coronary syndrome (ACS) requires accurate diagnosis for timely intervention.
  • Electrocardiogram (ECG) findings are crucial in differentiating myocardial infarction (MI) types.
  • Left circumflex artery (LCx) dissection is a rare but serious cause of ACS.

Observation:

  • A patient presented with ACS, showing specific ECG changes: upsloping ST depression in leads I, II, V3-V6 and ST elevation in lead aVR.
  • Coronary angiography identified a spontaneous dissection in a large, dominant LCx artery as the sole coronary lesion.
  • During percutaneous coronary intervention (PCI) of the LCx dissection, distal occlusion occurred, supplying the posterior descending artery.

Findings:

  • The distal LCx occlusion resulted in ST elevation myocardial infarction (STEMI).
  • The ECG pattern of STEMI showed ST elevation in leads III and aVF, but notably not in lead II.
  • This specific ECG manifestation was interpreted as indicative of a right coronary artery (RCA) territory MI, despite the primary event being in the LCx artery.

Implications:

  • This case highlights the importance of recognizing atypical ECG presentations in complex coronary artery pathologies.
  • It underscores the potential for misattribution of MI location based solely on standard ECG criteria when non-coronary artery disease (non-CAD) events or complex anatomical variations are involved.
  • Understanding these nuances is critical for guiding appropriate therapeutic strategies and improving patient outcomes in interventional cardiology.