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The role of E2F8 in the human placenta
Masako Mizuno1, Rika Miki2, Yoshinori Moriyama1
1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan.
Molecular Medicine Reports
|November 3, 2018
Summary
E2F transcription factor 8 (E2F8) is found in human placental cells. Unlike in mice, E2F8 appears to suppress extravillous trophoblast invasion, suggesting a different role in human placental development.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Cell Biology
Background:
- E2F transcription factor 8 (E2F8) is crucial for murine placental growth.
- The function of E2F8 in human placental development is currently unknown.
- Extravillous trophoblast (EVT) invasion is vital for human placenta formation.
Purpose of the Study:
- To investigate the localization and function of E2F8 in the human placenta.
- To compare the effects of E2F8 depletion on human EVT cell behavior.
Main Methods:
- Histological examination of E2F8 localization in human placenta.
- Detection of E2F8 mRNA in primary cultured human EVTs.
- Comparison of cell cycle, proliferation, invasion, and adhesion in E2F8-depleted (shE2F8) versus control (shControl) human EVT cell lines (HTR-8/SVneo).
Main Results:
- E2F8 was localized in decidual cells, EVTs, and cytotrophoblasts.
- E2F8 mRNA expression was confirmed in primary EVTs.
- E2F8 depletion significantly increased EVT invasive ability (~2-fold) and matrix metalloproteinase-1 production, without affecting cell cycle, proliferation, or adhesion.
Conclusions:
- E2F8 is present in human placental EVTs and cytotrophoblasts.
- E2F8 may suppress EVT invasiveness in the human placenta, contrasting with its role in murine placenta.
- Further research is needed to fully elucidate the distinct functions of E2F8 in human placental development.
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