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Cognition and functionality in delusional disorder.

Covadonga M Díaz-Caneja1, Jorge A Cervilla2, Josep M Haro3

  • 1Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Calle Ibiza, 43, 28009, Madrid, Spain.

European Psychiatry : the Journal of the Association of European Psychiatrists
|November 3, 2018
PubMed
Summary
This summary is machine-generated.

Cognitive impairments, particularly verbal memory deficits, significantly impact psychosocial functioning and disability in delusional disorder (DD). These findings highlight the potential benefit of cognitive interventions for patients with DD.

Keywords:
Functional outcomeNeurocognitionNeuropsychologyParanoiaPsychosisPsychosocial functioning

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Neurocognition is known to influence functional outcomes in schizophrenia.
  • The impact of cognition on functionality in delusional disorder (DD) has not been previously studied.

Purpose of the Study:

  • To assess the effect of clinical characteristics, symptom dimensions, and neuropsychological performance on psychosocial functioning in DD.
  • To evaluate the predictors of self-perceived functional impairment in DD.

Main Methods:

  • Seventy-five patients with diagnosed DD underwent neurocognitive testing (verbal memory, attention, working memory, executive functions).
  • Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale, with factor scores for Paranoid, Cognitive, Affective, and Schizoid dimensions.
  • Hierarchical linear regression models were used to identify predictors of functioning (Global Assessment of Functioning) and disability (Sheehan's Disability Inventory).

Main Results:

  • Higher Paranoid and Cognitive symptom scores were associated with poorer psychosocial functioning.
  • Impaired verbal memory was linked to poorer psychosocial functioning and higher self-perceived disability.
  • Deficits in executive functions were also associated with increased self-perceived disability.

Conclusions:

  • Impaired verbal memory and cognitive symptoms significantly affect functionality in DD, independent of paranoid symptom severity.
  • Cognitive interventions may play a crucial role in managing functional impairments in delusional disorder.