Age (autoimmunity) associated B cells (ABCs) and their relatives
Swati Phalke1, Philippa Marrack1
1Department of Biomedical Research, National Jewish Health, 1400, Jackson St., Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Current Opinion in Immunology
|November 3, 2018
Summary
B cells are diverse immune cells. Some B cells unexpectedly express T-bet (Tbx21), a transcription factor typically found in T cells, influencing immune responses and disease, particularly autoimmunity.
Area of Science:
- Immunology
- Cell Biology
Background:
- B cells are crucial for adaptive immunity, acting as antibody producers and antigen-presenting cells to T cells.
- B cell heterogeneity contributes to diverse immune responses.
- The transcription factor T-bet (Tbx21), usually associated with T cells, is unexpectedly found in some B cell populations.
Purpose of the Study:
- To discuss the heterogeneity of T-bet expressing B cells and related cells.
- To explore the role of T-bet positive B cells in various health and disease contexts.
Main Methods:
- Literature review and synthesis of existing research on T-bet expressing B cells.
- Analysis of B cell subpopulations and their functions.
Main Results:
- T-bet expressing B cells are found in elderly mice, humans, and in various infectious and autoimmune conditions.
- These T-bet positive B cells, and related cells, can influence disease progression, notably in autoimmunity where they are precursors for autoantibody production.
Conclusions:
- T-bet expression in B cells represents a significant aspect of immune cell heterogeneity.
- Understanding T-bet positive B cells is crucial for comprehending immune responses and developing strategies for autoimmune diseases.
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