Targeting Long Noncoding RNA in Glioma: A Pathway Perspective.
Junyang Li1, Yihao Zhu1, Handong Wang1
1Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Molecular Therapy. Nucleic Acids
|November 3, 2018
Summary
Long noncoding RNAs (lncRNAs) are key players in cancer biology, especially in gliomas. This review highlights their regulatory roles, potential as glioma biomarkers, and clinical significance.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are integral to cellular processes and are often uniquely expressed in specific tissues or cancers.
- Aberrant expression of lncRNAs is a hallmark of various cancers, including gliomas, where they perform diverse functions.
Purpose of the Study:
- To provide an overview of the regulatory mechanisms of lncRNAs in glioma cellular processes.
- To identify specific lncRNAs with potential as diagnostic or prognostic biomarkers for glioma.
- To discuss the clinical implications and therapeutic potential of targeting lncRNAs in glioma.
Main Methods:
- Literature review and synthesis of existing research on lncRNAs in glioma.
- Analysis of studies reporting lncRNA expression patterns in glioma tissues and cell lines.
- Evaluation of functional studies investigating the role of lncRNAs in glioma pathogenesis.
Main Results:
- lncRNAs significantly regulate critical cellular processes in glioma, such as proliferation, apoptosis, and invasion.
- Several lncRNAs have been identified as potential glioma biomarkers due to their differential expression and correlation with clinical outcomes.
- lncRNAs demonstrate potential for targeted therapies and as indicators for personalized medicine in glioma treatment.
Conclusions:
- lncRNAs represent a crucial layer of gene regulation in glioma with significant functional roles.
- Specific lncRNAs hold promise as valuable biomarkers for glioma diagnosis, prognosis, and treatment monitoring.
- Further research into lncRNA functions and clinical applications could lead to novel therapeutic strategies for glioma patients.
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