Related Experiment Video
Updated: Feb 3, 2026

Complementation of Splicing Activity by a Galectin-3 - U1 snRNP Complex on Beads
Published on: December 9, 2020
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity
Manpreet Kaur1, Dhaneshwar Kumar1, Vincent Butty2
1Indian Institute of Science Education and Research Mohali, Sector 81 SAS Nagar, PO Manauli, Mohali, Knowledge City 140306, Punjab, India.
Galectin-3 constrains CD8+ T cell responses against gamma-herpesvirus (MHV68). Inhibiting galectin-3 in T cells enhances anti-viral immunity and improves viral control in mice.
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- Gamma-herpesvirus (MHV68) infection activates CD8+ T cells.
- Understanding T cell activation pathways is crucial for controlling viral infections.
Purpose of the Study:
- To investigate the molecular mechanisms of MHV68-specific CD8+ T cell activation.
- To explore the role of galectin-3 in anti-MHV68 immunity.
Main Methods:
- Comprehensive transcriptomic analysis of activated versus naive CD8+ T cells.
- Investigated galectin-3 recruitment to the immunological synapse.
- Utilized galectin-3 knockout mice to assess anti-viral responses.
Main Results:
- Thousands of transcripts were differentially expressed in activated T cells.
- Galectin-3 was highly upregulated and recruited to the immune synapse.
- Galectin-3 knockout mice showed enhanced MHV68-specific CD8+ T cell responses and better viral control.
Conclusions:
- Galectin-3 negatively regulates CD8+ T cell activation during MHV68 infection.
- Targeting intracellular galectin-3 could enhance T cell-mediated anti-viral immunity.
- Inhibiting galectin-3 presents a potential strategy for improving control of viral infections.
More Related Videos
06:57In Vitro Culture for H5N1-Specific Duck T Cells and Detection of Immune Responses Using Intracellular Cytokine Staining Method
Published on: May 30, 2025
09:32Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
Related Concept Videos
Cell Specific Gene Expression
What is the Immune System?
pH Regulation in Cells
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Regulated mRNA Transport
Epigenetic Regulation
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...