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Updated: Feb 3, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
840
Squamous cell carcinoma-A rare pancreatic exocrine malignancy
Ahsan Wahab1, Juan Jose Gonzalez1, Vishal Devarkonda1
1a Internal Medicine Department , McLaren Regional Medical Center , Flint , MI , USA.
Cancer Biology & Therapy
|November 4, 2018
Summary
This case study details a rare instance of metastatic squamous cell carcinoma (SCC) of the pancreas in a patient with a strong family history of pancreatic cancer. Further research is needed to explore potential familial mutations.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pancreatic cancer typically presents as adenocarcinoma, with distinct genetic profiles.
- Squamous cell carcinoma (SCC) of the pancreas is exceptionally rare, with limited data on its genetic underpinnings and familial associations.
Observation:
- A 65-year-old female presented with obstructive jaundice and abdominal symptoms.
- Imaging revealed a pancreatic head mass with venous occlusion, enlarged lymph nodes, and hepatic lesions.
- Biopsy confirmed metastatic tumor cells positive for CK7, P40, and GATA3, indicative of poorly differentiated SCC.
Findings:
- The patient was diagnosed with metastatic SCC of the pancreas.
- Immunohistochemistry confirmed SCC, and PET-CT identified pancreatic, hepatic, and retroperitoneal metastatic sites.
- The patient had a significant family history of pancreatic cancer, suggesting a potential genetic predisposition.
Implications:
- This case highlights the rare occurrence of pancreatic SCC and its potential link to familial cancer syndromes.
- Further investigation into genetic mutations, such as BRCA-2, is warranted in familial pancreatic SCC.
- Understanding these rare presentations is crucial for accurate diagnosis and personalized treatment strategies.
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