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Developing combination immunotherapies against cancer that make sense
André Veillette1,2,3, Dominique Davidson4
1Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec H2W1R7, Canada. andre.veillette@ircm.qc.ca.
Science Immunology
|November 4, 2018
Summary
Combination immunotherapies targeting programmed cell death protein 1 (PD-1) and Glucocorticoid-induced tumor necrosis factor receptor (GITR) may synergize. Preclinical data suggest this approach could be effective for treating human cancers.
Area of Science:
- Immunology
- Oncology
- Preclinical Cancer Research
Background:
- Cancer immunotherapy has revolutionized treatment.
- Targeting immune checkpoints like PD-1 is a validated strategy.
- Novel combinations are needed to overcome resistance and improve efficacy.
Purpose of the Study:
- To investigate the potential synergistic effects of combining PD-1 and GITR pathway inhibition.
- To provide a mechanistic rationale for this combination in human cancer.
Main Methods:
- Mechanistic preclinical studies were conducted.
- The studies focused on the interplay between PD-1 and GITR signaling pathways.
Main Results:
- Preclinical data strongly support the hypothesis of synergy.
- The combination of PD-1 and GITR targeting shows promise.
Conclusions:
- Combination immunotherapy targeting PD-1 and GITR warrants further investigation in human cancer.
- This approach may offer enhanced anti-tumor responses.
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