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An ultrasensitive sensor based on quantitatively modified upconversion particles for trace bisphenol A detection.

Qiaofeng Li1,2, Jialei Bai1, Shuyue Ren1

  • 1Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental and Operational Medicine, Academy of Military Medical Science, Academy of Military Science, Da Li Road 1, Tianjin, 300050, China.

Analytical and Bioanalytical Chemistry
|November 4, 2018
PubMed
Summary

This study developed a highly sensitive sensor for detecting trace amounts of Bisphenol A (BPA), an endocrine-disrupting chemical. The novel sensor utilizes fluorescence resonance energy transfer (FRET) for accurate BPA detection in various water samples.

Keywords:
Bisphenol AQuantitative modificationSensorUpconversion particles

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Bisphenol A (BPA) is an endocrine-disrupting chemical with significant environmental and health risks.
  • Existing detection methods for BPA often suffer from low sensitivity and complex sample preparation.
  • There is a need for ultrasensitive and efficient sensors for trace BPA detection.

Purpose of the Study:

  • To develop an ultrasensitive sensor for the detection of trace Bisphenol A (BPA).
  • To utilize fluorescence resonance energy transfer (FRET) between modified upconversion nanoparticles (UCNPs) and tetramethylrhodamine for enhanced sensitivity.
  • To overcome limitations of low luminous efficiency and low sensitivity in existing BPA sensors.

Main Methods:

  • Synthesized and quantitatively modified upconversion nanoparticles (UCNPs) with high fluorescence efficiency.
  • Employed fluorescence resonance energy transfer (FRET) between modified UCNPs and tetramethylrhodamine for BPA detection.
  • Optimized detection conditions and validated sensor performance in various water matrices.

Main Results:

  • Achieved quantitative modification of UCNPs with specific concentrations of amino groups and streptavidin.
  • Established a linear relationship between UCNP fluorescence intensity and the logarithm of BPA concentration.
  • Demonstrated a low detection limit of 0.05 ng/mL for BPA.
  • Obtained high recovery rates (91.0-115.0%) in tap water, river water, and disposable paper cup water without complex pre-processing.

Conclusions:

  • The developed sensor exhibits ultrasensitivity and high efficiency for trace BPA detection.
  • The FRET-based sensor offers a promising tool for monitoring BPA contamination in environmental water samples.
  • The sensor is suitable for effective and reliable sensing of trace BPA due to its simplicity and accuracy.