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Updated: Feb 3, 2026

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
Published on: April 7, 2022
Echocardiographic assessment of left ventricular systolic function
Lars Gunnar Klaeboe1,2, Thor Edvardsen3,4
1Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Rikshospitalet, PO Box 4950, 0424, Oslo, Norway.
Abstract:
Left ventricular (LV) ejection fraction (LVEF) is the most validated and commonly used echocardiographic measure of systolic function. LVEF has a unique position in cardiology having severed as selection criteria for therapeutic trials that constitute the evidence base of today's treatment recommendations. Assessment of LV systolic function by global longitudinal strain (GLS) from speckle tracking echocardiography (STE) is a sensitive and feasible method that overcomes many of the limitations of LVEF, including reproducibility issues of serial testing and detection of LV dysfunction in pathologically remodeled hearts. This review discusses the role of STE as a complementary method to LVEF in estimation of LV systolic function.
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