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Updated: Feb 3, 2026

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Patient-specific requirements and clinical validation of MRI-based pressure mapping: A two-center study in patients

Leonid Goubergrits1, Florian Hellmeier1, Dominik Neumann2

  • 1Institute for Computational and Imaging Science in Cardiovascular Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.

Journal of Magnetic Resonance Imaging : JMRI
|November 4, 2018
PubMed

Insights

MRI-based pressure mapping accurately assesses aortic coarctation, offering a noninvasive alternative to cardiac catheterization. This method provides equivalent results when sufficient image resolution is achieved, enabling safer treatment planning.

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Diagnostic Radiology

Background:

  • Invasive peak-to-peak pressure gradients from cardiac catheterization are the standard for assessing aortic coarctation.
  • Cardiac catheterization carries inherent risks and is purely diagnostic unless an intervention is performed.

Purpose of the Study:

  • To validate Magnetic Resonance Imaging (MRI)-based pressure mapping against cardiac catheterization-derived pressure drop.
  • To establish minimal clinical requirements for accurate MRI-based pressure mapping.

Main Methods:

  • A prospective clinical validation study involving 27 patients with aortic coarctation undergoing cardiac catheterization.
  • Utilized 1.5T MRI with 4D velocity-encoded sequences and 3D anatomical imaging.
  • Calculated pressure drop using pressure mapping based on the pressure Poisson equation, comparing results with catheterization data.

Main Results:

  • MRI pressure mapping demonstrated significant equivalence to cardiac catheterization for pressure drop (17.5 ± 6.49 vs. 16.6 ± 6.53 mmHg, P < 0.001).
  • Equivalence was achieved in patients without imaging artifacts and with spatial resolution ≥5 voxels/diameter.

Conclusions:

  • MRI-based pressure mapping is an accurate, noninvasive method for assessing aortic coarctation, equivalent to invasive pressure gradients.
  • This technique is reliable for pre-procedural assessment in patients without prior stenting and with adequate image resolution, facilitating noninvasive treatment planning.
Abstract

Keywords:
4D VEC MRIaortic coarctationcatheterizationcongenital heart diseaseimage-based cardiovascular modelingnoninvasive diagnostics

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