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Updated: Feb 3, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Interactions of NIPAM nanogels with model lipid multi-bilayers: A neutron reflectivity study
Huihui Sun1, Katarzyna Zielinska1, Marina Resmini1
1Department of Chemistry, Queen Mary, University of London, Joseph Priestley Building, Mile End Road, London E1 4NS, United Kingdom.
Abstract:
In dermal drug delivery, the influence of the chemical structure of the carriers on their penetration mechanisms is not yet fully understood. This is a key requirement in order to design highly efficient delivery systems. In this study, neutron reflectivity is used to provide insights into the interactions between thermoresponsive N-isopropylacrylamide based nanogels, cross-linked with 10%, 20% and 30% N,N'-methylenebisacrylamide, and skin lipid multi-bilayers models. Ceramide lipid multi-bilayers and ceramide/cholesterol/behenic acid mixed lipid multi-bilayers were used for this work. The results indicated that in both multi-bilayers the lipids were depleted by the nanogels mainly through hydrophobic interactions. The ability of nanogels to associate with skin lipids to form water-dispersible complexes was found to be a function of the percentage cross-linker. An enhanced depletion of lipids was further observed in the presence of benzyl alcohol, a well-known skin penetration enhancer.
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