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Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation

Hongwei Tian1, Jingang Cui1, Chengzhi Yang1

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

BMC Cardiovascular Disorders
|November 5, 2018
PubMed

Insights

Left ventricular remodeling and larger left atrial size are significant predictors of atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) patients. These findings suggest that left ventricular remodeling contributes to AF development in HCM.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Electrophysiology

Background:

  • Atrial fibrillation (AF) is a common complication in hypertrophic cardiomyopathy (HCM).
  • Left atrial (LA) structural remodeling is linked to AF in HCM.
  • The role of left ventricular (LV) remodeling in AF presence within HCM patients remains under-evaluated.

Purpose of the Study:

  • To investigate the effect of LV remodeling on AF presence in HCM patients.
  • To assess LV remodeling using cardiovascular magnetic resonance (CMR).

Main Methods:

  • 394 HCM patients (293 HOCM, 101 NOHCM) were analyzed.
  • Patients were categorized into HCM with AF (n=50) and HCM without AF (n=344).
  • Data collected from hospital records; LV remodeling index (LVRI) and LA diameter assessed via CMR.

Main Results:

  • HCM patients with AF had significantly larger LA diameter and higher LVRI compared to those without AF.
  • LVRI positively correlated with LA size.
  • LVRI and LA size were independent determinants of AF in HCM, even after adjusting for age and LV end-diastolic mass index.

Conclusions:

  • HCM patients with AF exhibit increased LA diameter, LVRI, and age.
  • LV remodeling and LA size are strong, independent predictors of AF in HCM.
  • LV remodeling may play a contributing role in the development of AF in HCM patients.
Abstract

Keywords:
Atrial fibrillationHypertrophic cardiomyopathyLeft ventricular remodeling

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