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Updated: Feb 3, 2026
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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
12.5K
Management of Ventilator-Associated Pneumonia: Guidelines
Mark L Metersky1, Andre C Kalil2
1Division of Pulmonary, Critical Care and Sleep Medicine, University of Connecticut School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-1321, USA.
Clinics in Chest Medicine
|November 5, 2018
Summary
Two major guidelines offer differing advice on diagnosing ventilator-associated pneumonia (VAP) but agree on using local resistance data for initial antibiotic treatment and favoring shorter therapy durations.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pulmonology
Background:
- Recent guidelines address ventilator-associated pneumonia (VAP) diagnosis and treatment.
- Recommendations vary regarding diagnostic techniques and the role of biomarkers.
Purpose of the Study:
- To compare and contrast recent major guidelines on VAP management.
- To highlight key areas of agreement and divergence in VAP diagnostic and therapeutic recommendations.
Main Methods:
- Comparative analysis of two recent major clinical practice guidelines for VAP.
- Review of recommendations concerning empiric antibiotic therapy, diagnostic strategies, and treatment duration.
Main Results:
- Both guidelines emphasize local antibiotic resistance patterns and patient risk factors for empiric therapy.
- Guidelines diverge on the necessity of invasive diagnostic techniques for VAP.
- Both advocate for short-course antibiotic therapy for most VAP cases.
Conclusions:
- Clinical judgment, local resistance data, and patient risk are crucial for initial VAP antibiotic selection.
- Diagnostic approaches for VAP show variability between guidelines.
- Short-course therapy is a common recommendation, with differing views on procalcitonin's role in guiding treatment duration.
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