Genomics Testing and Personalized Medicine in the Preoperative Setting

Area of Science:

• Pharmacogenomics
• Perioperative Medicine
• Clinical Pharmacology

Background:

• Pharmacogenomics (PGx) studies genetic influences on drug responses.
• Its application in perioperative medicine is an emerging field.
• Current healthcare systems face challenges in PGx implementation.

Purpose of the Study:

• To review the evidence for PGx in perioperative drug categories.
• To identify challenges in integrating PGx into clinical workflows.
• To highlight the potential of PGx in perioperative care.

Main Methods:

• Literature review of current evidence on PGx in perioperative settings.
• Discussion of challenges in healthcare system integration.
• Analysis of PGx applications across various drug classes.

Main Results:

• PGx shows potential in optimizing perioperative drug selection for opioids, analgesics, sedatives, beta-blockers, antiemetics, and anticoagulants.
• Key challenges include physician adoption and electronic health record integration.
• Evidence supports PGx's role in improving perioperative medication management.

Conclusions:

• Pharmacogenomics holds significant promise for tailoring perioperative medication regimens.
• Overcoming implementation barriers is crucial for widespread PGx adoption.
• Further integration of PGx into clinical practice can enhance patient safety and outcomes.