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Updated: Feb 3, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Embryology of the Parathyroid Glands
Kristen Peissig1, Brian G Condie1, Nancy R Manley1
1Department of Genetics, University of Georgia, 500 DW Brooks Drive, Coverdell Building Suite 270, Athens, GA 30602, USA.
Abstract:
The parathyroid glands are essential for regulating calcium homeostasis in the body. The genetic programs that control parathyroid fate specification, morphogenesis, differentiation, and survival are only beginning to be delineated, but are all centered around a key transcription factor, GCM2. Mutations in the Gcm2 gene as well as in several other genes involved in parathyroid organogenesis have been found to cause parathyroid disorders in humans. Therefore, understanding the normal development of the parathyroid will provide insight into the origins of parathyroid disorders.
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