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Physiology of Parathyroid Hormone
1Department of Medicine and Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, Canada; Departments of Medicine and of Physiology, McGill University, 845 Sherbrooke St West, Montreal, Quebec H3A 0B9, Canada.
Endocrinology and Metabolism Clinics of North America
|November 5, 2018
Summary
Parathyroid hormone (PTH) is crucial for calcium balance, aiding kidney reabsorption and vitamin D activation. It
Area of Science:
- Endocrinology and Bone Metabolism
Background:
- Parathyroid hormone (PTH) is the primary secretion of the parathyroid glands.
- PTH plays a vital role in calcium homeostasis.
Purpose of the Study:
- To summarize the physiological roles of PTH in calcium regulation and bone metabolism.
- To highlight the clinical applications of PTH in treating hypoparathyroidism and osteoporosis.
Main Methods:
- Review of established physiological functions of PTH.
- Analysis of clinical uses based on PTH's effects on calcium and bone.
Main Results:
- PTH enhances renal calcium reabsorption and stimulates vitamin D production for intestinal absorption.
- PTH mobilizes bone calcium by increasing bone turnover, primarily in cortical bone.
- PTH demonstrates anabolic effects, promoting bone formation in trabecular and cortical bone.
Conclusions:
- PTH is a key regulator of calcium levels and bone remodeling.
- PTH replacement therapy is effective for hypoparathyroidism.
- PTH's anabolic properties are utilized for osteoporosis treatment.
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