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Related Experiment Video

Updated: Feb 3, 2026

Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Homocysteine and age-associated disorders.

E A Ostrakhovitch¹, S Tabibzadeh¹

¹Frontiers in Bioscience Research Institute in Aging and Cancer, Irvine, CA, USA.

Ageing Research Reviews

|November 5, 2018

Summary

This summary is machine-generated.

High homocysteine levels accelerate aging and increase risks for cardiovascular, neurodegenerative, and kidney diseases. This review explores how elevated homocysteine impacts age-related cellular decline and disease progression.

Keywords:

Age associated diseases Aging Homocysteine Hyperhomocysteinemia Metabolism

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Area of Science:

Gerontology and Molecular Biology
Biochemistry and Metabolism

Background:

Aging is an inevitable process linked to cellular dysfunction, leading to various age-associated diseases.
Accumulated cellular damage, metabolic changes, and impaired protein clearance contribute to tissue degeneration and reduced quality of life.
Elevated homocysteine, a risk factor for cardiovascular and neurodegenerative diseases, increases with age due to declining renal function and altered methionine metabolism.

Purpose of the Study:

To review the impact of elevated homocysteine levels on age-related physiological changes.
To examine the contribution of homocysteine metabolism to the development and progression of age-associated diseases.
To highlight the link between homocysteine, oxidative stress, and mitochondrial dysfunction in aging tissues.

Main Methods:

Literature review of studies investigating aging mechanisms and homocysteine metabolism.
Analysis of research on the relationship between homocysteine levels and age-related diseases.
Synthesis of evidence on the role of homocysteine in cellular senescence and tissue degeneration.

Main Results:

High homocysteine is associated with increased risk of cardiovascular disease, neurodegeneration, and chronic kidney disease.
Impaired homocysteine metabolism contributes to oxidative stress, nitric oxide synthase pathway inactivation, and mitochondrial dysfunction.
Aging is characterized by declining renal function and metabolic deregulation, leading to elevated homocysteine levels.

Conclusions:

Elevated homocysteine is a significant factor in age-related tissue degeneration and disease.
Understanding homocysteine's role is crucial for developing interventions against age-associated pathologies.
Further research into homocysteine metabolism may offer therapeutic targets for mitigating aging effects.