Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

62.1K
Overview
62.1K
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

608
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
608
Chronic Pharyngitis01:23

Chronic Pharyngitis

11.9K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
11.9K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

740
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
740
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

443
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
443
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

318
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
318

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New Neuroendocrine Markers PITX2, PHOX2B, and HAND2 Do Not Offer Diagnostic Utility in Fine-needle Aspiration Biopsies of Primary and Secondary Medullary Thyroid Carcinomas: A Retrospective Multi-institutional Study.

Journal of clinical and translational pathology·2026
Same author

The Development Path of Gynecological Cytology after Papanicolaou: from Bethesda to Artificial Intelligence and Personalized Medicine.

Acta cytologica·2026
Same author

Cytopathology Terminology Systems: European Federation of Cytological Societies Survey on Practice in Europe.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same author

Persistent human papillomavirus following mild cytology at screening: implications for age-stratified follow-up and triage.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·2026
Same author

Navigating the International System for Reporting Serous Fluid Cytopathology in pericardial effusion: A meta-analysis.

Cancer cytopathology·2026
Same author

International Consensus Guidelines for Diagnostic Criteria and Checklist for Future Studies for Minimally Invasive Carcinoma ex Pleomorphic Adenoma: An HN CLEAR Initiative.

Head and neck pathology·2026

Related Experiment Video

Updated: Feb 3, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.5K

Neovascularization with chronic inflammation characterizes ascending aortic dissection.

Eetu Niinimäk, Ville Pynnönen, Ivana Kholova

  • 1Departments of Pathology, Fimlab Laboratories, *Heart Center, Cardiac Research, Tampere University Hospital and Tampere University Medical School; Tampere-Finland. ari.mennander@hotmail.com.

Anatolian Journal of Cardiology
|November 5, 2018
PubMed
Summary

Neovascularization, or new blood vessel growth, in the ascending aorta is linked to aortic dissection (AD). This process, associated with chronic inflammation, indicates increased susceptibility to AD and aortic wall disruption.

More Related Videos

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.1K
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
10:18

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Published on: June 29, 2014

17.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.5K
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.1K
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
10:18

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Published on: June 29, 2014

17.6K

Area of Science:

  • Cardiovascular pathology
  • Vascular biology
  • Surgical pathology

Background:

  • Aortic dissection (AD) is a serious cardiovascular condition.
  • Neovascularization of the aortic wall, indicated by CD31 deposition and chronic inflammation, is a potential factor in AD development.
  • Understanding the mechanisms of AD is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the presence and location of neovascularization in the ascending aorta.
  • To correlate neovascularization with aortic dissection (AD).
  • To assess the role of chronic inflammation and neovascularization in AD pathogenesis.

Main Methods:

  • Histological and immunohistochemical analysis of ascending aorta samples from 35 patients.
  • Characterization of CD31 positive endothelial cells to identify neovascularization.
  • Assessment of chronic inflammation and immune cell infiltration (T- and B-lymphocytes, plasma cells, macrophages).

Main Results:

  • Neovascularization was predominantly observed in the outer third medial layer of the aorta in patients with AD.
  • Aortic dissection (AD) was associated with increased chronic inflammation in the adventitia, media, and intima.
  • Receiver operating characteristic curve analysis confirmed neovascularization as a significant indicator of AD (AUC 0.750, p=0.022).

Conclusions:

  • Endothelial immunohistochemistry confirms neovascularization in the outer medial layer of the aorta during AD.
  • Aortic wall remodeling, including neovascularization, is a characteristic feature of AD.
  • Chronic inflammation and neovascularization in the dilated ascending aorta suggest increased susceptibility to AD.