Related Experiment Video

Updated: Feb 3, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.2K

The multi-disciplinary management of complex congenital and acquired tracheo-oesophageal fistulae

H S Thakkar1, R Hewitt2,3, K Cross1

  • 1Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.

Pediatric Surgery International
|November 5, 2018
PubMed

Insights

A multidisciplinary team (MDT) approach effectively manages complex tracheo-oesophageal fistulae (TOF) in children. This collaborative strategy aids decision-making for rare congenital and acquired TOF cases, improving patient outcomes.

Area of Science:

  • Pediatric Surgery
  • Otolaryngology
  • Gastroenterology

Background:

  • Complex tracheo-oesophageal fistulae (TOF) are rare pediatric conditions, presenting as congenital or acquired defects.
  • Management of these complex cases requires specialized expertise and coordinated care.

Purpose of the Study:

  • To evaluate the effectiveness of a multidisciplinary (MDT) approach in managing complex pediatric tracheo-oesophageal fistulae (TOF) over a five-year period.

Main Methods:

  • Retrospective data collection of pediatric patients with recurrent or acquired TOF.
  • Diagnostic investigations included CT scans, bronchoscopy, bronchogram, microlaryngobronchoscopy, and oesophagoscopy.
  • All cases were discussed in emergent MDT meetings for treatment planning.

Main Results:

  • 14 patients were included, with 50% congenital and 50% acquired TOF etiologies.
  • Acquired TOF cases included button battery ingestions and iatrogenic injuries post-oesophageal atresia repair.
  • Surgical repair was performed in most cases; 64% experienced complications, including anastomotic leak, vocal cord paresis, recurrence, and mortality.

Conclusions:

  • A multidisciplinary team (MDT) approach is crucial for managing complex pediatric tracheo-oesophageal fistulae (TOF).
  • Shared expertise within an MDT facilitates optimal decision-making for these rare and challenging cases.
Abstract

Keywords:
BronchoscopyButton batteryCardio-pulmonary bypassRecurrent tracheo-oesophageal fistulaThoracotomy

More Related Videos

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

7.5K
Technical Aspects of the Mouse Aortocaval Fistula06:12

Technical Aspects of the Mouse Aortocaval Fistula

Published on: July 11, 2013

17.5K

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
423
Complex Numbers01:29

Complex Numbers

The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
310
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.1K
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
429