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Updated: Feb 3, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine Headache: Updates and Future Developments
Parker E Bohm1, Fernando F Stancampiano2, Todd D Rozen1
1Department of Neurology, Mayo Clinic, Jacksonville, FL.
Mayo Clinic Proceedings
|November 6, 2018
Summary
Recent migraine research reveals new targeted therapies and nonpharmacological options. These advances offer more treatment choices for patients, especially those ineligible for traditional triptans.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a prevalent, disabling neurological condition often managed in primary care.
- Increasing therapeutic options complicate patient management.
- Advances in understanding migraine pathophysiology are crucial.
Purpose of the Study:
- To review recent updates in migraine treatment.
- To discuss future directions in migraine therapy.
- To highlight novel therapeutic targets and modalities.
Main Methods:
- Literature review of recent studies on migraine pathophysiology and treatment.
- Analysis of new pharmacological and non-pharmacological interventions.
- Focus on targeted therapies and emerging treatment options.
Main Results:
- New understanding of migraine pathophysiology involves biomarkers and genetics.
- Targeted therapies include monoclonal antibodies against calcitonin gene-related peptide (CGRP).
- Other novel treatments include CGRP receptor antagonists and 5-HT1F agonists.
- Nonpharmacological options like noninvasive brain stimulation are also available.
Conclusions:
- Novel migraine treatments offer alternatives, particularly for patients unresponsive to or ineligible for triptans.
- Advances in targeted therapies and nonpharmacological interventions expand treatment paradigms.
- Continued research into pathophysiology will drive future migraine management strategies.
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