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Updated: Feb 3, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Conversion to open from laparoscopic colon resection is a marker for worse oncologic outcomes in colon cancer
Leonardo de Castro Duraes1, Scott R Steele1, Mariane Gouvêa Monteiro de Camargo1
1Department of Colorectal Surgery, Cleveland Clinic Foundation, Crile Building, 2049 East 100th Street, Cleveland, OH, 44195, USA.
Background:
This study aimed to evaluate the oncological outcomes of conversion in patients undergoing resection for colon cancer.
Methods:
Patients with stages I-III colon adenocarcinoma operated on between 2000 and 2012 were included. Oncologic outcomes were assessed by surgical approach (laparoscopy vs. open). A secondary analysis compared patients who required conversion to open vs. laparoscopic only.
Results:
We identified 1196 patients that met inclusion criteria (28% laparoscopic, 72% open). Overall, 13% of laparoscopic cases were converted to open. There were no differences in 5-year overall survival (OS) (p = 0.258), disease-free survival, (DFS) (p = 0.070), cancer-specific survival (CSS) (p = 0.207), or recurrence (p = 0.216) between laparoscopy and open surgery. However, patients with conversion had a worse OS (p = 0.010) and DFS (p = 0.006) when compared to laparoscopic only.
Conclusion:
Conversion from laparoscopic to open surgery is a marker for worse survival outcomes. Further investigation is needed to define the underlying cause of these differences.
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