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Updated: Feb 3, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Interest of pharmacoepidemiology for the study of inhaled drugs
Mathieu Molimard1, Pierre-Olivier Girodet2, Eric Van Ganse3
1Service of medical pharmacology, university of Bordeaux, CHU de Bordeaux, 33076 Bordeaux, France; Inserm, UMR 1219, Bordeaux population health research center, team pharmacoepidemiology, 33000 Bordeaux, France.
Abstract:
Pharmacoepidemiology studies are of particular interest in the respiratory field and especially for inhaled drugs. In real-life, excessive use of rescue medications and under- or inappropriate-prescribing of preventer medications has been shown. In asthma and chronic obstructive pulmonary disease (COPD), the poor use of inhalation device is associated with uncontrolled diseases and occurrence of exacerbations. Inhalation treatments are directly delivered within the lung and are generally considered as safe. However, systemic adverse drug reactions that were not evidenced in clinical trials may be observed after a long-term treatment.
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